We have not used RefWorks a whole lot ourselves (at least I have not used it as extensively as I probably should), but we have tested it from on campus, off campus, and on the wireless network, and have not really run across any major issues.
Today I was speaking with a student who was experiencing quite a bit of trouble exporting and importing citations from home using RefWorks and I have, so far, not been able to pinpoint the problem she was having nor resolve it. If you are experiencing problems exporting and importing citations using RefWorks from home — let us know. Better yet, copy down the error messages that display and send them in an email message to us. We want this tool to actually be useful for you & not just a huge headache.